During illness and trauma, metabolic changes include increased hepatic glucose production, decreased peripheral glucose utilization, and increased protein breakdown.

• A. Increased hepatic glucose production with increased peripheral glucose utilization
• B. Increased hepatic glucose production with decreased peripheral glucose utilization
• C. Increased hepatic glucose production, decreased peripheral glucose utilization, and increased protein breakdown
• D. Decreased hepatic glucose production with increased protein synthesis

Answer: (C)