EFAD in CF is associated with malabsorption of which nutrients?

• A. Carbohydrates
• B. Fat and fat-soluble vitamins
• C. Minerals
• D. Proteins

Answer: (B)

In cystic fibrosis, pancreatic exocrine insufficiency reduces lipase secretion, so fats aren’t digested and absorbed well. Fats are the vehicles for fat-soluble vitamins A, D, E, and K, so when fat absorption drops, these vitamins are also poorly absorbed. Essential fatty acids—needed for many bodily functions—are supplied with fats, so their absorption is also impaired. That’s why essential fatty acid deficiency in CF arises from fat malabsorption, not primarily from problems with carbohydrates, proteins, or minerals. Management focuses on pancreatic enzyme replacement and fat-soluble vitamin (and essential fatty acid) supplementation to correct this deficiency.