How does the prevalence of chronic cholestasis relate to the duration of PN usage?

• A. It decreases with longer PN usage
• B. It shows no relation to PN duration
• C. It increases with longer PN usage
• D. It fluctuates randomly with PN duration

Answer: (C)

The main idea is that the longer someone is on parenteral nutrition, the higher the chance of developing PN-associated cholestasis. Prolonged PN means extended biliary stasis from not using the gut, reduced enteral stimulation of bile flow, and potential lipid-related liver stress; over time, this hepatobiliary injury accumulates, so the prevalence rises with longer PN duration. It does not inherently decrease with time, nor is it unrelated or random. Short-term PN carries some risk, but the risk increases as exposure to PN extends.