In aging, what happens to plasma free fatty acids?

• A. Decreased free fatty acids
• B. Increased free fatty acid concentrations
• C. No change
• D. Lower fat mobilization

Answer: (B)

As people age, adipose tissue tends to become more lipolytically active, and insulin’s ability to suppress that process declines. This means more triglycerides are broken down and released as free fatty acids into the bloodstream. Increased sympathetic activity with aging and often reduced physical activity further boost lipolysis, while muscle and tissue uptake of fatty acids can be less efficient, slowing clearance. The result is higher circulating plasma free fatty acid concentrations in many older adults, rather than a drop or no change.