In cancer-related malnutrition, weight loss varies with cancer type, location, grade, and stage. This statement is:

• A. True
• B. False
• C. Not known
• D. Not applicable

Answer: (A)

Weight loss in cancer-related malnutrition varies because different cancers drive malnutrition through different mechanisms, and this variation depends on the tumor’s type, location, aggressiveness, and extent. Some cancers with high metabolic activity and systemic inflammation—such as pancreatic, gastroesophageal, and certain lung cancers—tend to cause more rapid weight loss and cachexia. The tumor’s location can influence appetite, digestion, and nutrient absorption, while the stage reflects tumor burden and the duration of catabolic signals, both of which affect how much weight is lost. Grade indicates how aggressive the cancer is, which can amplify metabolic disturbance and weight loss risk. All of these factors together explain why weight loss is not uniform across cancers.

Thus the statement is true. Saying it is false would contradict observed patterns in cancer cachexia, and options suggesting uncertainty or applicability away from the clinical reality do not fit the evidence.