In cirrhosis, what metabolic change supports the use of fat as energy during overnight fasting?

• A. Depleted glycogen stores
• B. Increased fat oxidation
• C. Increased glycogen synthesis
• D. Decreased fat oxidation

Answer: (A)

The main idea is how the body shifts fuel sources during a fasting period. Normally, the liver’s glycogen provides the first energy during an overnight fast. In cirrhosis, glycogen stores are diminished, so there isn’t enough carbohydrate energy available. Once glycogen is exhausted, the body increases fat breakdown and oxidation to supply the needed energy, supporting fat as a fuel source during the fast. Increased fat oxidation would occur as a consequence of depleted glycogen, while increased glycogen synthesis or decreased fat oxidation would not promote fat use in this scenario.