RNA and DNA are hydrolyzed to form mononucleotides during the digestion of which biomolecule?

• A. Carbohydrates
• B. Nucleic acids
• C. Proteins
• D. Fats

Answer: (B)

Nucleic acids are polymers of nucleotides, and during digestion their phosphodiester bonds are cleaved by nucleases, releasing mononucleotides. This is specific to nucleic acids, whereas carbohydrates break down to monosaccharides, proteins to amino acids, and fats to glycerol and fatty acids. So RNA and DNA are hydrolyzed to form mononucleotides during the digestion of nucleic acids.