What is the theory behind omega-3 supplementation in cystic fibrosis?

• A. Omega-3s directly increase exocrine pancreatic function
• B. Omega-3s help counteract EFAD due to fat malabsorption and may modulate inflammation
• C. Omega-3 cures CF
• D. Omega-3s worsen pulmonary status

Answer: (B)

In cystic fibrosis, fat malabsorption from pancreatic insufficiency often leads to essential fatty acid deficiency. The theory behind omega-3 supplementation is to address this deficiency and to modulate inflammation in the lungs. Omega-3 fats, especially EPA and DHA, can shift the fatty acid balance away from pro-inflammatory mediators derived from arachidonic acid and toward less inflammatory or pro-resolving compounds. This dual idea— correcting EFAD and reducing inflammatory activity—forms the basis for considering omega-3s as an adjunct in CF care. They are not a cure and do not directly improve exocrine pancreatic function, nor do they worsen pulmonary status; rather, they are considered for potential anti-inflammatory benefits and EFAD correction.