Which of the following is NOT a typical sign of iron deficiency anemia?

• A. Polyphagia
• B. Fatigue
• C. Pallor
• D. Headache

Answer: (A)

Iron deficiency anemia causes signs related to reduced oxygen delivery to tissues. Fatigue appears because muscles and organs receive less oxygen for energy; pallor shows the low hemoglobin level; headaches can result from decreased oxygen to the brain. Appetite changes are not a feature of this condition. While some individuals with iron deficiency may develop pica (craving nonnutritive substances like ice), a general increase in appetite or polyphagia is not typical. So the sign that doesn’t fit the usual pattern is polyphagia.