Which statement accurately describes the relationship between meconium ileus and high-dose pancreatic enzyme therapy?

• A. Meconium ileus is caused by high-dose enzyme therapy.
• B. Meconium ileus is not caused by high-dose enzyme therapy.
• C. Meconium ileus has no relation to enzyme therapy.
• D. Meconium ileus is unrelated to enzyme therapy.

Answer: (B)

Meconium ileus in newborns is a congenital obstruction caused by thick, sticky meconium in the ileum, which is a classic manifestation of cystic fibrosis. Pancreatic enzyme replacement therapy is given later to help CF patients digest fats and proteins and to treat pancreatic insufficiency. It does not cause the meconium obstruction. In fact, the obstruction is a result of the underlying CF-related mucus abnormalities, not from taking enzymes. While very high doses of pancreatic enzymes can cause gastrointestinal symptoms, they are not responsible for meconium ileus. Therefore, the statement that meconium ileus is not caused by high-dose enzyme therapy is the accurate understanding.