Why is short-acting insulin (regular) typically used when initiating enteral nutrition?

• A. It has longer duration than basal insulin
• B. It is more cost-effective
• C. Tolerance and titration may be unpredictable, minimizing hypoglycemia if enteral nutrition is interrupted
• D. It provides basal coverage

Answer: (D)

Short-acting insulin is preferred here because its effects track the carbohydrate load from enteral feeds and can be adjusted quickly as the feeding rate changes or if the feed is interrupted. Its action is relatively predictable and temporary, so you can titrate up or down to match the current nutrition delivery without causing prolonged hypoglycemia if the feed is paused. Basal (background) coverage, which provides a constant insulin level, is supplied by long-acting insulins, not regular.